CLINICAL STUDIES

NUTRITIONAL SUPPLEMENT IMPROVES FERTILITY IN WOMEN

Lynn M. Westphal, MD, Mary Lake Polan, MD, PhD, MPH*, Aileen Sontag Trant, PhD

Objective: To determine the impact of nutritional supplementation on female fertility.

Design: A double-blind, placebo-controlled study was initiated to determine the effects of FertilityBlend for Women, a proprietary nutritional supplement containing chasteberry and green tea extracts, L-arginine, vitamins (including folate) and minerals. Changes in progesterone level, basal body temperature, menstrual cycle, pregnancy rate and side effects were monitored.

Results: Ninety-three (93) women, age 24-42 years, who had tried unsuccessfully to conceive for six to 36 months, completed the study. After three months, the FertilityBlend (FB) supplement group (N=53 vs. 40 in placebo group) demonstrated a strong trend toward an increase in mean mid-luteal phase progesterone (from 8.2 to 10.4 ng/ml, p=0.06).  Among women initially low in progesterone (<12 ng/ml, N=34 in FB and 23 in placebo group), the increase in the FB group with low progesterone was highly significant (4.9 to 9.3 ng/ml; p=0.005). The average number of days in cycle with basal temperatures over 98F during luteal phase also increased significantly in the overall FB group (5.5 to 8.1 days, p=0.006). Among women starting with short cycles (<27 days, N=15 in FB and N=9 in placebo group), mean cycle length increased significantly in the FB group (from 24.2 to 27.6 days; p<0.001).  Among women with longer cycles (>32 days, N=11 in FB and 6 in placebo group), cycles tended to shorten in the FB group (from 41.6 to 31.7; p=0.02). The placebo group overall (N=40) did not show any notable changes after treatment, in any of the parameters studied. After six months, 17 of the 53 women in the FB group were pregnant (32%), and four of the 40 women in the placebo group were pregnant (10%; p<0.01). No significant side effects were noted.

Conclusion: Nutritional supplementation may provide an attractive alternative or complement to conventional fertility therapies.

Journal of Women's Health . May2005;14(4):365.

CLINICAL STUDY OF FERTILITYBLEND, A NUTRITIONAL SUPPLEMENT USED FOR THE OPTIMIZATION OF REPRODUCTIVE HEALTH IN WOMEN.

LM Westphal, MD, ML Polan, MD, PhD, MPH, AS Trant, PhD, SB Mooney, MD

Objective: To determine the impact of nutritional supplementation on the optimization of reproductive health in women.

Study Design: A double-blind, placebo-controlled pilot study was initiated to determine the effects of FertilityBlend, a proprietary nutritional supplement containing chasteberry and green tea extracts, L-arginine, vitamins (including folate) and minerals. Changes in progesterone level, basal body temperature, menstrual cycle, pregnancy rate and side effects were monitored.

Results: Thirty (30) women, age 24-46 years, who had tried unsuccessfully to conceive for six to 36 months completed the study. After three months, the supplement group (N=15) demonstrated a trend toward an increase in mean mid-luteal phase progesterone level (from 8.2 to 12.8 ng/ml, p=0.08); also a significant increase in the average number of days in cycle with basal temperatures over 37C (98F) during luteal phase (6.8 to 9.7 days, p=0.04). The placebo group (N=15) did not show any notable changes after treatment, in any of the parameters studied. After five months, five of the 15 women in the supplement group were pregnant (33%), and none of the 16 women in the placebo group were pregnant (p<0.01). No significant side effects were noted.

Conclusion: Nutritional supplementation may provide an attractive alternative or complement to conventional fertility therapies.

*Dr. Polan is a member of the Scientific Advisory Board and received stock options in the company for her service.

If you are a man with low to moderate sperm count or motility, or a woman with PCOS interested in participating in the ongoing study, see below:

ONGOING CLINICAL STUDY

If you are a male, with low to moderate sperm count or motility, or a women with PCOS, and live in the San Francisco Bay area, you may want to participate in a clinical study on improving fertility.  Contact Dr. Aileen Trant at 650-988-8588 x212 for further details. You must be able to make 2-3 visits to Stanford University Medical School to participate.

What's in it for you?  Fertility analyses (progesterone tests in women and semen analysis in men) are done at Stanford free of charge, and after completion of the study you receive a three month's supply of FertilityBlend.

ADDITIONAL STUDIES

Below are list of published scientific and medical studies that support the effectiveness and safety of the individual ingredients in FertilityBlend.

Clinical Studies:

• Brown DJ.  1995.  Vitex agnus castus.  Clinical Monograph.  Townsend Letters for Doctors and Patients, October.

• Propping D, et al.  1988.  Diagnosis and therapy of corpus luteum insufficiency in general practice.  Therapiewoche 38:2992-3001.

• Caan B, et al.  1998.  Differences in fertility associated with caffeinated beverage consumption.  Am J Public Health 88(2):270-4.

• Bayer R.  1960.  Treatment of infertility with vitamin E.  Int J Fertil 5:70-8.

• Rushton DH, et al. 1991.  Ferritin and fertility.  Lancet 337:1554.

• McCloud D.  1996.  Female infertility: a holistic approach.  Aust J Med Herbalism 8(3):68-77.

• Czeizel AE.  1998.  Periconceptual folic acid containing multivitamin supplementation.  Eur J Obstet Gynecol Reprod Biol 78(2):151-61.

Clinical Studies:

• Costa M, et al.  1994.  L-carnitine in ideopathic asthenospermia: a multicenter study.  Andrologia 26:155-9.

• Zheng R-L and Zhang H. 1997. Effects of ferulic acid on fertile and asthenozoospermic infertile human sperm motility, viability, lipid peroxidation, and cyclic nucleotides. Free Rad Biol & Med 22(4):581-6.

• Kessopoulou E, et al. 1995. A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated with male infertility. Fertil & Steril 64(4):825-31.

• Geva E, et al. 1996. The effect of antioxidant treatment on human spermatazoa and fertilization rate in an in vitro fertilization program.  Fertil & Steril 66(3):430-4.

• Dawson EB, et al. 1992. Effect of ascorbic acid supplementation on the sperm quality of smokers. Fertil & Steril 58(5):1034-9.

• Scott R, et al. 1998. The effect of oral selenium supplementation on human sperm motility. Br J Urol 82:76-80.

• Moriyama H, et al. 1987. Studies on the usefulness of a long-term, high-dose treatment of methylcobalamin in patients with oligozoospermia.  Hin Kiyo 33(1):151-6.

• Takihara H, et al.  1987.  Zinc sulphate therapy for infertile male with or without varicocelectomy.  Urol 29(6):638-41.

• Czeizel AE.  1998.  Periconceptual folic acid containing multivitamin supplementation.  Eur J Obstet Gynecol Reprod Biol 78(2):151-61.

FertilityBlend For Women (Back to product)

Home » Pregnancy » Fertility

FertilityBlend For Women FertilityBlend is the nationally recognized fertility supplement that is clinically-validated by a study done at Stanford University School of Medicine, and has helped hundreds of thousands of couples safely and naturally improve their fertility health. These may include couples that have no health issues but wanted to ensure a healthy pregnancy, as well as couples that have experienced difficulty in conceiving. Here's why it can help you too: FertilityBlend is the only multi-ingredient formula clinically-validated by a study done at Stanford University's School of Medicine, with remarkable results. FertilityBlend comes in two unique formulations for Women and for Men. FertilityBlend takes a more gradual, gentle approach, without the undesirable side effects and high costs of traditional fertility treatments. FertilityBlend is the only combination fertility supplement that has undergone the "gold standard" of scientific testing: a double-blind, placebo-controlled study. The data speaks for itself. (See Clinical Studies for results) Other products claiming "OBGyn/Doctor recommended" or "scientifically validated" have NOT had their actual formulas tested to this important standard of safety and efficacy. All their claims should be viewed with caution. The only way to ensure a multi-ingredient formula is safe and effective is to test that exact combination in a well-controlled clinical study. FertilityBlend has also been awarded a U.S. patent on its proprietary formulation and every ingredient is standardized to ensure lot-to-lot consistency and potency. After being carefully reviewed by the media and peer-review physician journals, the credibility of these formulas and associated clinical research has warranted published medical journal articles and attention from the national press. How it works FertilityBlend for Women and FertilityBlend for Men were developed based on published scientific literature on nutritional components that benefit fertility and have a safe history of usage. All ingredients have been scientifically studied to determine their individual benefits. The formulas have showed excellent results and safety in studies conducted with Stanford University Medical School. To see the results of those studies, click here. Created by leading researchers, FertilityBlend is the first nutritional product to synergistically combine key natural ingredients into specifically designed men's and women's formulations. FertilityBlend for Women: The herb, Vitex (chasteberry), supports good hormone balance and normal ovulation. The amino acid, L-Arginine , helps maintain healthy uterine lining. Antioxidants, green tea, vitamin E, and selenium, help enhance reproductive health by repairing oxidative damage due to aging and environmental toxins. The ingredient folic acid assists in the reduction of neural tube defects in children, as part of a healthy diet. The vitamins B6 and B12, and the minerals, iron, zinc and magnesium also promote fertility health.* FertilityBlend for Men: The amino acid, L-carnitine, has been shown to be critical to the formation of healthy sperm. Vitamins C and E, green tea and selenium are all potent antioxidants that help improve sperm counts and quality. The antioxidant ferulic acid is found in Dong Quai, has also been shown to improve sperm quality. Ingredients zinc and B vitamins (B6, B12 and folate) are critical nutrients in male reproductive systems for several benefits, including hormone metabolism, sperm formation and motility. Supplement Facts FertilityBlend for Women FertilityBlend for Men   FertilityBlend Clinical Proof FAQ
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