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CLINICAL STUDIES

NUTRITIONAL SUPPLEMENT IMPROVES FERTILITY IN WOMEN

Lynn M. Westphal, MD, Mary Lake Polan, MD, PhD, MPH*, Aileen Sontag Trant, PhD

Objective: To determine the impact of nutritional supplementation on female fertility.

Design: A double-blind, placebo-controlled study was initiated to determine the effects of FertilityBlend for Women, a proprietary nutritional supplement containing chasteberry and green tea extracts, L-arginine, vitamins (including folate) and minerals. Changes in progesterone level, basal body temperature, menstrual cycle, pregnancy rate and side effects were monitored.

Results: Ninety-three (93) women, age 24-42 years, who had tried unsuccessfully to conceive for six to 36 months, completed the study. After three months, the FertilityBlend (FB) supplement group (N=53 vs. 40 in placebo group) demonstrated a strong trend toward an increase in mean mid-luteal phase progesterone (from 8.2 to 10.4 ng/ml, p=0.06).  Among women initially low in progesterone (<12 ng/ml, N=34 in FB and 23 in placebo group), the increase in the FB group with low progesterone was highly significant (4.9 to 9.3 ng/ml; p=0.005). The average number of days in cycle with basal temperatures over 98F during luteal phase also increased significantly in the overall FB group (5.5 to 8.1 days, p=0.006). Among women starting with short cycles (<27 days, N=15 in FB and N=9 in placebo group), mean cycle length increased significantly in the FB group (from 24.2 to 27.6 days; p<0.001).  Among women with longer cycles (>32 days, N=11 in FB and 6 in placebo group), cycles tended to shorten in the FB group (from 41.6 to 31.7; p=0.02). The placebo group overall (N=40) did not show any notable changes after treatment, in any of the parameters studied. After six months, 17 of the 53 women in the FB group were pregnant (32%), and four of the 40 women in the placebo group were pregnant (10%; p<0.01). No significant side effects were noted.

Conclusion: Nutritional supplementation may provide an attractive alternative or complement to conventional fertility therapies.

Journal of Women's Health . May2005;14(4):365.


CLINICAL STUDY OF FERTILITYBLEND, A NUTRITIONAL SUPPLEMENT USED FOR THE OPTIMIZATION OF REPRODUCTIVE HEALTH IN WOMEN.

LM Westphal, MD, ML Polan, MD, PhD, MPH, AS Trant, PhD, SB Mooney, MD

Objective: To determine the impact of nutritional supplementation on the optimization of reproductive health in women.

Study Design: A double-blind, placebo-controlled pilot study was initiated to determine the effects of FertilityBlend, a proprietary nutritional supplement containing chasteberry and green tea extracts, L-arginine, vitamins (including folate) and minerals. Changes in progesterone level, basal body temperature, menstrual cycle, pregnancy rate and side effects were monitored.

Results: Thirty (30) women, age 24-46 years, who had tried unsuccessfully to conceive for six to 36 months completed the study. After three months, the supplement group (N=15) demonstrated a trend toward an increase in mean mid-luteal phase progesterone level (from 8.2 to 12.8 ng/ml, p=0.08); also a significant increase in the average number of days in cycle with basal temperatures over 37C (98F) during luteal phase (6.8 to 9.7 days, p=0.04). The placebo group (N=15) did not show any notable changes after treatment, in any of the parameters studied. After five months, five of the 15 women in the supplement group were pregnant (33%), and none of the 16 women in the placebo group were pregnant (p<0.01). No significant side effects were noted.

Conclusion: Nutritional supplementation may provide an attractive alternative or complement to conventional fertility therapies.

*Dr. Polan is a member of the Scientific Advisory Board and received stock options in the company for her service.

If you are a man with low to moderate sperm count or motility, or a woman with PCOS interested in participating in the ongoing study, see below:

ONGOING CLINICAL STUDY

If you are a male, with low to moderate sperm count or motility, or a women with PCOS, and live in the San Francisco Bay area, you may want to participate in a clinical study on improving fertility.  Contact Dr. Aileen Trant at 650-988-8588 x212 for further details. You must be able to make 2-3 visits to Stanford University Medical School to participate.

What's in it for you?  Fertility analyses (progesterone tests in women and semen analysis in men) are done at Stanford free of charge, and after completion of the study you receive a three month's supply of FertilityBlend.

ADDITIONAL STUDIES

Below are list of published scientific and medical studies that support the effectiveness and safety of the individual ingredients in FertilityBlend.

Clinical Studies:

  • Brown DJ.  1995.  Vitex agnus castus.  Clinical Monograph.  Townsend Letters for Doctors and Patients, October.

  • Propping D, et al.  1988.  Diagnosis and therapy of corpus luteum insufficiency in general practice.  Therapiewoche 38:2992-3001.

  • Caan B, et al.  1998.  Differences in fertility associated with caffeinated beverage consumption.  Am J Public Health 88(2):270-4.

  • Bayer R.  1960.  Treatment of infertility with vitamin E.  Int J Fertil 5:70-8.

  • Rushton DH, et al. 1991.  Ferritin and fertility.  Lancet 337:1554.

  • McCloud D.  1996.  Female infertility: a holistic approach.  Aust J Med Herbalism 8(3):68-77.

  • Czeizel AE.  1998.  Periconceptual folic acid containing multivitamin supplementation.  Eur J Obstet Gynecol Reprod Biol 78(2):151-61.

Clinical Studies:

  • Costa M, et al.  1994.  L-carnitine in ideopathic asthenospermia: a multicenter study.  Andrologia 26:155-9.

  • Zheng R-L and Zhang H. 1997. Effects of ferulic acid on fertile and asthenozoospermic infertile human sperm motility, viability, lipid peroxidation, and cyclic nucleotides. Free Rad Biol & Med 22(4):581-6.

  • Kessopoulou E, et al. 1995. A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated with male infertility. Fertil & Steril 64(4):825-31.

  • Geva E, et al. 1996. The effect of antioxidant treatment on human spermatazoa and fertilization rate in an in vitro fertilization program.  Fertil & Steril 66(3):430-4.

  • Dawson EB, et al. 1992. Effect of ascorbic acid supplementation on the sperm quality of smokers. Fertil & Steril 58(5):1034-9.

  • Scott R, et al. 1998. The effect of oral selenium supplementation on human sperm motility. Br J Urol 82:76-80.

  • Moriyama H, et al. 1987. Studies on the usefulness of a long-term, high-dose treatment of methylcobalamin in patients with oligozoospermia.  Hin Kiyo 33(1):151-6.

  • Takihara H, et al.  1987.  Zinc sulphate therapy for infertile male with or without varicocelectomy.  Urol 29(6):638-41.

  • Czeizel AE.  1998.  Periconceptual folic acid containing multivitamin supplementation.  Eur J Obstet Gynecol Reprod Biol 78(2):151-61.

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FertilityBlend For Men

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Fertility Blend for Men is a fertility supplement that aims to maintain male reproductive health. It uses specially selected ingredients that work with your body potentially helping you conceive. As well as focusing on sperm motility and health, it is also used by many men who are worried about their sperm count. Fertility Blend for Men is a clinically proven supplement with thousands of satisfied couples and men worldwide.

  • Designed especially for men
  • Made using all natural ingredients
  • Used by many men concerned about their sperm count and sperm motility
  • Suitable for vegetarians
  • Discreet to take
  • Has already helped thousands of couples worldwide

This male fertility supplement is a popular product for men who either have a low sperm count or low sperm motility. If you suffer from either or both of these, then Fertility Blend for Men may be the answer for you.

  • Description
  • Ingredients
  • Directions

What is Fertility Blend for Men?

It is a male fertility supplement known to potentially support your chances of conception. Trying for a baby can be a wonderful process, however it can be stressful if you keep trying to no avail. The reasons for this could be low male sperm count or low level sperm motility. Fertility Blend for Men is used by many men to help combat both these fronts. The natural blend of ingredients including Green Tea and Dong Quai may contribute to maintaining that your conception chances are as high as possible.

For best results, couples found that when this fertility supplement was used alongside Fertility Blend for Women, they achieved maximum results.

Why should I take it?

There are many reasons as to why you should take any male fertility supplement. But there are many specific reasons as to why you should buy this one. It is made using a specially formulated blend of natural ingredients. Each ingredient was chosen to support and maintain male fertility and male reproductive health. Fertility Blend for Men was scientifically tested at Stanford University Medical School, USA. This entire process means that you can use this supplement in confidence that you are in safe hands.

What are the main ingredients and how can they help?

A few of the main ingredients in the Fertility Blend for Men are Dong Quai, Zinc and B Vitamins (B6, B12 and Folate) and Green Tea.

Dong Quai- From regions of Korea, Japan and China. It’s been used for thousands of years in ancient medicines. Now it is used in family planning solutions thanks to its antioxidant properties and ferulic acids that are believed to improve sperm quality.

Zinc and B Vitamins (B6, B12 and Folate)- These all help to promote stabile sperm formulation, motility and hormone metabolism.

Green Tea- This is one of the most well-known and commonly used extracts in the world. For centuries is has been use to help support the male reproductive system.

Ingredient list (per 2 capsules)- Vitamins C (as ascorbic acid) 120mg, Vitamin E (as dl alpha tocopheryl acetate) 150UI, Vitamin B6 (as pyridoxine hydrochloride) 2mg, Vitamin B12 (as cyanocobalamin) 6mcg, Folate (as folic acid) 400mcg, Zinc (as gluconate) 15mg, Selenium (as sodium selenite) 70mcg. Other ingredients include Silica, Magnesium Stearate, Rice Flour Powder.

Is Fertility Blend for Men safe to take?

Yes it is. It is not a drug and has been created by experts using specially selected ingredients. It's been made to help those struggling with family planning and conception issues. If and when taken as directed you should not experience any unwanted side effects.

How do you take this fertility supplement?

The great thing is that you only have to take 2 easy to swallow capsules a day. One in the morning and the other in the evening. For faster results and in the first 2 months, you can increase this dosage to 3-4 capsules per day. Please note that for best results you must continue use for at least 3 months.

Ingredients

Serving Size: 2 Capsules
Servings Per Container: 30

Ingredient Amount Per Serving

Vitamin C (as ascorbic acid)

120 mg

Vitamin E (as dl alpha tovopheryl acetate)

150 IU

Vitamin B6 (as pyridoxine hydrochlorided)

2 mg

Vitamin B12 (as cyanocobalamin)

6 mcg

Folate (as folic acid)

400 mcg

Zinc (as gluconate)

15 mg

Selenium (as sodium selenite)

70 mcg

 
Proprietay Blend
  • L-Carnitine fumarate
  • Green Tea (Camellia sinensis) standard leaf extract
  • Dong quai (Angelica sinensis) standard root extract
 
Other ingredients
  • Rice flour powder, Magnesium stearate, Silica

Directions

Take 1 capsules twice a day with or without food.

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1 x FertilityBlend For Men (60 Caps) - £29.16
 
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