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CLINICAL STUDIES

NUTRITIONAL SUPPLEMENT IMPROVES FERTILITY IN WOMEN

Lynn M. Westphal, MD, Mary Lake Polan, MD, PhD, MPH*, Aileen Sontag Trant, PhD

Objective: To determine the impact of nutritional supplementation on female fertility.

Design: A double-blind, placebo-controlled study was initiated to determine the effects of FertilityBlend for Women, a proprietary nutritional supplement containing chasteberry and green tea extracts, L-arginine, vitamins (including folate) and minerals. Changes in progesterone level, basal body temperature, menstrual cycle, pregnancy rate and side effects were monitored.

Results: Ninety-three (93) women, age 24-42 years, who had tried unsuccessfully to conceive for six to 36 months, completed the study. After three months, the FertilityBlend (FB) supplement group (N=53 vs. 40 in placebo group) demonstrated a strong trend toward an increase in mean mid-luteal phase progesterone (from 8.2 to 10.4 ng/ml, p=0.06).  Among women initially low in progesterone (<12 ng/ml, N=34 in FB and 23 in placebo group), the increase in the FB group with low progesterone was highly significant (4.9 to 9.3 ng/ml; p=0.005). The average number of days in cycle with basal temperatures over 98F during luteal phase also increased significantly in the overall FB group (5.5 to 8.1 days, p=0.006). Among women starting with short cycles (<27 days, N=15 in FB and N=9 in placebo group), mean cycle length increased significantly in the FB group (from 24.2 to 27.6 days; p<0.001).  Among women with longer cycles (>32 days, N=11 in FB and 6 in placebo group), cycles tended to shorten in the FB group (from 41.6 to 31.7; p=0.02). The placebo group overall (N=40) did not show any notable changes after treatment, in any of the parameters studied. After six months, 17 of the 53 women in the FB group were pregnant (32%), and four of the 40 women in the placebo group were pregnant (10%; p<0.01). No significant side effects were noted.

Conclusion: Nutritional supplementation may provide an attractive alternative or complement to conventional fertility therapies.

Journal of Women's Health . May2005;14(4):365.


CLINICAL STUDY OF FERTILITYBLEND, A NUTRITIONAL SUPPLEMENT USED FOR THE OPTIMIZATION OF REPRODUCTIVE HEALTH IN WOMEN.

LM Westphal, MD, ML Polan, MD, PhD, MPH, AS Trant, PhD, SB Mooney, MD

Objective: To determine the impact of nutritional supplementation on the optimization of reproductive health in women.

Study Design: A double-blind, placebo-controlled pilot study was initiated to determine the effects of FertilityBlend, a proprietary nutritional supplement containing chasteberry and green tea extracts, L-arginine, vitamins (including folate) and minerals. Changes in progesterone level, basal body temperature, menstrual cycle, pregnancy rate and side effects were monitored.

Results: Thirty (30) women, age 24-46 years, who had tried unsuccessfully to conceive for six to 36 months completed the study. After three months, the supplement group (N=15) demonstrated a trend toward an increase in mean mid-luteal phase progesterone level (from 8.2 to 12.8 ng/ml, p=0.08); also a significant increase in the average number of days in cycle with basal temperatures over 37C (98F) during luteal phase (6.8 to 9.7 days, p=0.04). The placebo group (N=15) did not show any notable changes after treatment, in any of the parameters studied. After five months, five of the 15 women in the supplement group were pregnant (33%), and none of the 16 women in the placebo group were pregnant (p<0.01). No significant side effects were noted.

Conclusion: Nutritional supplementation may provide an attractive alternative or complement to conventional fertility therapies.

*Dr. Polan is a member of the Scientific Advisory Board and received stock options in the company for her service.

If you are a man with low to moderate sperm count or motility, or a woman with PCOS interested in participating in the ongoing study, see below:

ONGOING CLINICAL STUDY

If you are a male, with low to moderate sperm count or motility, or a women with PCOS, and live in the San Francisco Bay area, you may want to participate in a clinical study on improving fertility.  Contact Dr. Aileen Trant at 650-988-8588 x212 for further details. You must be able to make 2-3 visits to Stanford University Medical School to participate.

What's in it for you?  Fertility analyses (progesterone tests in women and semen analysis in men) are done at Stanford free of charge, and after completion of the study you receive a three month's supply of FertilityBlend.

ADDITIONAL STUDIES

Below are list of published scientific and medical studies that support the effectiveness and safety of the individual ingredients in FertilityBlend.

Clinical Studies:

  • Brown DJ.  1995.  Vitex agnus castus.  Clinical Monograph.  Townsend Letters for Doctors and Patients, October.

  • Propping D, et al.  1988.  Diagnosis and therapy of corpus luteum insufficiency in general practice.  Therapiewoche 38:2992-3001.

  • Caan B, et al.  1998.  Differences in fertility associated with caffeinated beverage consumption.  Am J Public Health 88(2):270-4.

  • Bayer R.  1960.  Treatment of infertility with vitamin E.  Int J Fertil 5:70-8.

  • Rushton DH, et al. 1991.  Ferritin and fertility.  Lancet 337:1554.

  • McCloud D.  1996.  Female infertility: a holistic approach.  Aust J Med Herbalism 8(3):68-77.

  • Czeizel AE.  1998.  Periconceptual folic acid containing multivitamin supplementation.  Eur J Obstet Gynecol Reprod Biol 78(2):151-61.

Clinical Studies:

  • Costa M, et al.  1994.  L-carnitine in ideopathic asthenospermia: a multicenter study.  Andrologia 26:155-9.

  • Zheng R-L and Zhang H. 1997. Effects of ferulic acid on fertile and asthenozoospermic infertile human sperm motility, viability, lipid peroxidation, and cyclic nucleotides. Free Rad Biol & Med 22(4):581-6.

  • Kessopoulou E, et al. 1995. A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated with male infertility. Fertil & Steril 64(4):825-31.

  • Geva E, et al. 1996. The effect of antioxidant treatment on human spermatazoa and fertilization rate in an in vitro fertilization program.  Fertil & Steril 66(3):430-4.

  • Dawson EB, et al. 1992. Effect of ascorbic acid supplementation on the sperm quality of smokers. Fertil & Steril 58(5):1034-9.

  • Scott R, et al. 1998. The effect of oral selenium supplementation on human sperm motility. Br J Urol 82:76-80.

  • Moriyama H, et al. 1987. Studies on the usefulness of a long-term, high-dose treatment of methylcobalamin in patients with oligozoospermia.  Hin Kiyo 33(1):151-6.

  • Takihara H, et al.  1987.  Zinc sulphate therapy for infertile male with or without varicocelectomy.  Urol 29(6):638-41.

  • Czeizel AE.  1998.  Periconceptual folic acid containing multivitamin supplementation.  Eur J Obstet Gynecol Reprod Biol 78(2):151-61.

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FertilityBlend For Women

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The miracle of birth is a wonderful thing, but it may be hard to conceive for many couples. That’s were Fertility Blend for Women comes into the picture. It is a scientifically formulated fertility supplement that helps maintain the health of the female reproductive system. Fertility Blend for Women has been used for years by couples hoping to conceive.

  • A first choice for couples around the world
  • Supports you and your partner on your quest to conceive
  • Made using high quality natural ingredients
  • Formula specially made for women
  • Contains ingredients such as Green Tea and Chasteberry

Providing your body with essential vitamins, minerals and nutrients, Fertility Blend for Women is a natural formula popular with women hoping to conceive. It uses effective ingredients often linked to the health of the female reproductive system. Use of this fertility supplement allows you to join the thousands of other couples who have benefitted from the Fertility Blend range.

  • Description
  • Ingredients
  • Directions

What is Fertility Blend for Women?

This is a fertility supplement especially made for women who are finding it difficult to conceive. Although this may be down to a number of reasons, some of them can be overcome with a little extra help. Fertility Blend for Women is made with natural ingredients, many of which contain properties known to help the female reproductive organs. Ingredients such as Chasteberry, Green Tea and Chaste Tea are all included.

Developed by scientists at the coveted Stanford University Medical School, each capsule contains ingredients that work with your body to maintain a hospitable place for semen to thrive.

Who can I use it?

Fertility Blend for Women is specifically for women, unlike other solutions that are neither here nor there. If you are find it hard to conceive or would simply like to increase your chances, choosing natural options to help is usually very beneficial. As well as this natural options can also help to maintain a healthy hormone balance in your body alongside ensuring your body has the perfect condition for conception.

Since this Fertility Blend product launched, it has already helped thousands of couples worldwide and now you can get help too.

How do the ingredients help?

All of the ingredients in this natural fertility supplement have been chosen specifically to work with you and your body, which is why it is so popular with women hoping to optimise their chances of getting pregnant.

Chasteberry- otherwise known as Vitex helps to maintain a good hormonal balance to promote ovulation.

Green Tea- big in antioxidant levels, it helps you keep your reproductive organs in very good condition. They have also been used in traditional medicines for centuries.

Chaste Tea- from the Mediterranean and Central Asia, it stimulates the luteinizing hormone, which can be very important in ovulation. It’s also been used for centuries to balance hormonal levels.

Other ingredients include Vitamin E, Vitamin B6, VitaminB12, Folate, Iron, Magnesium, Zinc and Selenium. For the full list of ingredients, please refer to the box.

Is this a drug?

Fertility Blend for Women fertility supplement is not a drug. It’s been made using only natural ingredients. You do not require a prescription to use or purchase it.

Is it safe to use?

As mentioned above, Fertility Blend for Women is made using natural ingredients so you should not experience any unwanted side effects. We do advice you to check all ingredients prior to use to ensure you aren't allergic to any.

How do I take them?

You should take one capsule 3 times a day. If possible you should spread the dosages throughout the day. Use 3 days before a menstrual cycle to make the most impact.

Ingredients

Serving Size: 3 Capsules
Servings Per Container: 30

Ingredient Amount Per Serving

Vitamin E (as dl alpha tovopheryl acetate)

150 IU

Vitamin B6 (as pyridoxine hydrochlorided)

6 mg

Vitamin B12 (as cyanocobalamin)

12 mcg

Folate (as folic acid)

400 mcg

Iron (as gluconate)

9 mg

Magnesium (as oxide)

400 mcg

Zinc (as gluconate)

15 mg

Selenium (as sodium selenite)

70 mcg

 
Proprietay Blend
  • L-Arginine
  • Green Tea (Camellia sinensis) standard leaf extract
  • Chaseberry (Vitex agnus-castus) standard berry extract
 
Other ingredients
  • Rice flour powder, Magnesium stearate, Silica

How do I take them?

You should take one capsule 3 times a day. If possible you should spread the dosages throughout the day. Use 3 days before a menstrual cycle to make the most impact.

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FertilityBlend For Women (90 Caps) - £29.16
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FertilityBlend For Women (180 Caps) - £49.00 Save £9.32

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Combo 1 x FertilityBlend For Men and 1 x FertilityBlend For Women - £49.00 Save £9.32

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1 x FertilityBlend For Men (60 Caps) - £29.16
 
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2 x FertilityBlend For Men (120 Caps) - £49.00 Save £9.32

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